England have set Pakistan a goal of 355 runs, courtesy a century by in-form batter Harry Brook, within the second Take a look at on the Multan Cricket Stadium.
The correct-hander scored 108 runs in 149 balls with the assistance of 14 fours and a six.
The guests have been dismissed of 275 of their second innings with Abrar Ahmed claiming figures of 4-120. Debutant Abrar completed with a match haul of 11 wickets.
Zahid Mahmood additionally bagged three wickets for the hosts within the second innings.
Earlier, spinner Jack Leach took Four for 98 as Pakistan have been bundled out for 202, giving England a 79-run first-innings lead and placing them in a powerful place to take the Take a look at sequence — their first in Pakistan in 17 years.
Within the morning session of day two, Pakistan´s batters wasted a powerful place after they resumed at 107-2 with skipper Babar Azam and Shakeel trying to construct a strong lead.
However as soon as Azam was bowled by quick bowler Ollie Robinson for 75 within the seventh over of the day, the innings collapsed with seven wickets falling for simply 37 runs.